
凭证GLP-1R作用时间,,,,GLP-1R激动剂可以分为短效和长效两大类。。。
Based on their ability to activate GLP-1 receptor,,,,GLP-1 receptor agonists can be classified as short- acting and long-acting GLP-1R agonist.
短效GLP-1R 激动剂,,,,需要逐日一次或者逐日两次给药。。。
Short-acting GLP-1R agonists are required to give either a once daily (QD) or twice-daily(BID)dosing.
如艾塞那肽和利西拉肽等,,,,长效GLP-1R激动剂是对化合物分子举行了一些结构修饰,,,,这样可以增强其作用时间,,,,同时保存其作用于GLP-1R 的能力.如杜拉鲁肽、阿必鲁肽等,,,,每周给药一次即可。。。
For example Exenatide and Lixisenatide, long acting GLP-1R agonists have undergone some structural modifications to enhance their duration of action while retaining their ability to act on the GLP-1 receptors. For example Albiglutide,Dulaglutide, once weekly.
【平台】“GLP-1”新药研发效劳平台
【视频】GLP-1 作用机制
【视频】GLP-1s 的心理作用
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