KRAS卵白包括4个结构域
。。。。。KRAS卵白由6条β-折叠链和5条-螺旋结构组成，，，，，，，形成两个主要结构域：G结构域和C端结构域
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KRAS protein contains 4 domains.KRAS protein is made up of 6 beta-strands and 5 alpha-helicies, which form two major domains: G-domain and C-terminal.

KRAS的G结构域由残基1-166组成，，，，，，，包括GTP连系口袋，，，，，，，该区域关于下游效应物和GTPase激活卵白之间的相互之间作用至关主要
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The G-domain  of KRAS, comprised of residues 1-166, includes the GTP-binding pocket, a region within which is essential for the interactions between the putative downstream effectors and GTPase-activating proteins.

G结构域是高度守旧的，，，，，，，包括认真GTP-GTP交流的switch Ⅰ和switch Ⅱ区域
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The G domain is highly conserved and contains switch Ⅰ and switch Ⅱ loops, which are responsible for GDP-GTP exchange.

C端是一个包括CAAX基序的高变区，，，，，，，指导翻译后修饰并决议细胞膜锚定，，，，，，，该区域在RAS卵白的生物活性调控中起着主要作用
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The C-terminal, a hypervariable region including the CAAX motif, guides posttranslational modifications and determines plasma membrane anchoring. This region plays an important role in the regulation of the biological activity of RAS protein.

KRAS新药研发平台

什么是KRAS?

CA88助力信诺维抗肿瘤1类新药XNW14010（小分子KRAS G12C卵白共价连系抑制剂）获批临床